The Duke Department of Mathematics has partnered with TriCEM to host a virtual seminar from Trevor Graham of the Barts Cancer Institute at Queen Mary University of London. Please join us for this exciting cancer evolution seminar!
Inferring the Dynamics of Cancer Evolution with Genomics and Population Genetics
Trevor Graham, PhD
Thursday, February 4th, 2021
12-1pm EST
Zoom (Meeting ID: 958 9031 1491, passcode: 702886)
As tumours grow, each cell within the tumour independently accumulates new mutations. The pattern genetic heterogeneity between tumour cells (intra-tumour heterogeneity – ITH) is read out of the evolutionary dynamics of cancer growth. Here I will discuss our work to mathematically model ITH and parameterise these models using genomic data. We show how positive, negative and neutral selection the shapes pattern of ITH and report the frequency of these evolutionary patterns across cancer types. We explore the influence of spatial processes on the detectability of evolutionary dynamics.
References:
- https://www.nature.com/articles/s41588-020-0687-1
- https://www.nature.com/articles/s41588-020-0675-5
- https://elifesciences.org/articles/48714
- https://www.nature.com/articles/s41588-020-0675-5
- https://www.nature.com/articles/s41588-018-0128-6
- https://www.nature.com/articles/ng.3489
- Recent review: https://www.annualreviews.org/doi/10.1146/annurev-genom-083117-021712
